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目的观察连续性肾脏替代疗法(CRRT)治疗重症急性肾功能衰竭(ARF)的疗效和对预后的影响。方法对2003年以来16例ARF(伴发多器官功能障碍综合征,MODS)患者进行CRRT的临床资料回顾性分析。结果11例患者经CRRT治疗24 h后,生命指征平稳,BUN、Scr下降(P<0.05),二氧化碳结合力(CO2CP)正常,85~264h后进入多尿期;5例患者死于严重创伤或MODS。治疗过程中无低体温和低血压等并发症。结论CRRT治疗重症ARF患者,血液动力学稳定,溶质清除率高,有利于营养支持及清除炎性细胞因子,从而改善重症ARF患者的预后。
Objective To observe the curative effect and prognosis of continuous renal replacement therapy (CRRT) on severe acute renal failure (ARF). Methods The clinical data of 16 CRFT patients from 16 ARF patients with multiple organ dysfunction syndrome (MODS) since 2003 were retrospectively analyzed. Results After 11 hours of CRRT treatment, the signs of life were stable, the BUN and Scr were decreased (P <0.05), and the carbon dioxide binding capacity (CO 2 CP) was normal. After 85 ~ 264 hours, Or MODS. No hypothermia and hypotension during the treatment of complications. Conclusions CRRT treatment of severe ARF patients with hemodynamic stability, high solute clearance, is conducive to nutritional support and clear inflammatory cytokines, thereby improving the prognosis of patients with severe ARF.