论文部分内容阅读
测定了下列气水界面单分子膜的表面压-平均分子面积等温线：（1）d-α－；d-β-，d-γ-，和d-δ-生育酚等4种维生素E与DPPC，DOPC及DLPC的混合物；（2）d-α-生育酚等摩尔比的DPPC和DLPC的混合物；（3）胆固醇与DPPC，DLPC的混合物。讨论了维生素E色满环上甲基对其在PC单分子膜中物理化学作用的影响，实验结果表明：（1）维生素E以d－α－＞d-β≈d－γ－＞d-δ-的次序引起DPPC单分子膜的膨胀，以相反的次序使DOPC单分子膜凝缩。（2）维生素E可降低DPPC单分子膜的崩裂压，但不引起DOPC和DLPC单分子膜崩裂压的改变。（3）向等摩尔比的DOPC和DLPC的混合单分子膜中混入生育酚不改变膜的崩裂压，但引起膜的膨胀。（4）与一般认为生育酚和胆固醇在磷脂膜中的物理化学作用彼此类似的看法不同，它们有着明显的差别
The surface pressure-average molecular-area isotherms of the monolayers at the gas-water interface were determined as follows: (1) d-α-; d-β-, d- γ-, and d-δ- A mixture of DPPC, DOPC and DLPC; (2) a mixture of DPPC and DLPC in equimolar proportions of d-alpha-tocopherol; and (3) a mixture of cholesterol and DPPC, DLPC. The effect of methyl on the PC monolayer in vitamin E color-full ring was discussed. The experimental results showed that: (1) Vitamin E had the following properties: d-α-> d-β≈d- γ-> The order of δ- causes the DPPC monolayer to swell, condensing the DOPC monolayer in the reverse order. (2) vitamin E can reduce the DPPC monolayer cracking pressure, but does not cause changes in the DOPC and DLPC monolayers pressure collapse. (3) The incorporation of tocopherol into a mixed monomolecular membrane of DOPC and DLPC at an equal molar ratio did not change the collapse pressure of the membrane, but caused swelling of the membrane. (4) In contrast to the common belief that the physicochemical interactions of tocopherols and cholesterol in phospholipid membranes are similar to each other, they have significant differences