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为了探究血吸虫感染后免疫复合物肾病的发生、发展和预后,为临床及防治实践提供线索,本文对小鼠感染日本血吸虫及经有效药物治疗后不同时期肾脏内免疫复合物沉积和病理变化进行了观察。结果表明小鼠感染后18天,肾小球已出现微量的IgG和C_3沉积,感染后25天,反应增强并能检到IgM;感染后40天至2月,反应趋向高峰。至感染后3个月,IgG、IgM的沉积仍很明显,但补体的沉积开始减弱。用间接荧光抗体试验在肾切片上耒发现日本血吸虫抗原。感染后4周至2月,光镜下见肾小球毛细血管球萎缩,肾小球囊腔扩大,基底膜增厚,肾小管内有少量管型。电镜下见肾小球基底膜增厚,有色素沉积,电子密度的沉积呈驼峰样病变,提示有免疫复合物沉积。治疗后上述肾小球病变减轻,以致消失。
In order to explore the occurrence, development and prognosis of immunocomplex nephropathy after schistosoma infection, this study provided clues for clinical practice and prevention and treatment. In this paper, the immune deposition and pathological changes of immune complexes in mice after infection with Schistosoma japonicum and at different periods after effective drug treatment were studied Observed. The results showed that a small amount of IgG and C_3 deposition appeared on glomeruli 18 days after infection in mice. After 25 days of infection, the reaction was enhanced and IgM could be detected. From 40 days to February after infection, the reaction tended to peak. Three months after infection, the deposition of IgG and IgM remained significant, but the deposition of complement began to diminish. Indirect fluorescent antibody tests were performed on kidney sections to identify Schistosoma japonicum antigen. 4 weeks after infection to February, under the light microscope see glomerular capillary atrophy, glomerular balloon enlargement, basement membrane thickening, a small amount of tubular tubular. Electron microscope, see glomerular basement membrane thickening, pigmentation, deposition of electron density showed a hump-like lesions, suggesting the deposition of immune complexes. Glomerular lesions after treatment reduced, resulting in disappearance.