香菇多糖注射液系香菇(Lenfinus edodes)子实体的提取物,具有刺激免疫功能和抗肿瘤的作用;对白血病、食管癌、胃癌等病人治疗,证明有不同程度提高机体免疫功能的作用;对慢性迁延性肝炎患者有明显降低转氨酶的作用。本文观察该药对犬和大鼠的长期毒性,以便了解连续用药而产生的毒性作用,为临床用药提供安全性评价的实验依据。 Lentinus edodes extracts of Lentinus edodes fruit body have stimulating immune function and anti-tumor effects; treatment of patients with leukemia, esophageal cancer, gastric cancer, etc. have proved to have different degrees of improving the role of the body’s immune function; Patients with persistent hepatitis have significantly reduced the role of transaminases. This article observes the long-term toxicity of the drug to dogs and rats, in order to understand the toxic effects of continuous drug use, and to provide an experimental basis for clinical evaluation of safety.