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目的：观察一氧化氮（ｎｉｔｒｉｃｏｘｉｄｅ，ＮＯ）供体硝酸甘油对妊高征患者血中ＮＯ及内皮素（ｅｎｄｏｔｈｅｌｉｎ，ＥＴ）的影响，为使用硝酸甘油治疗妊高征提供理论依据。方法：于用药前、后３０分钟分别抽取患者肘静脉血。以Ｇｒｉｅｓｓ反应测定血清中ＮＯ的代谢产物及放射免疫法测定血浆中内皮素的含量，同时监测心功能参数。结果：妊高征病人使用硝酸甘油后，血中ＮＯ代谢产物明显增多（Ｐ＜０．０５），ＥＴ明显下降（Ｐ＜０．０５）ＥＴ与ＮＯ代谢产物的比值明显下降（Ｐ＜０．０５）。结论：硝酸甘油不仅可增加血中ＮＯ含量，而且可减少血中ＥＴ含量，纠正ＥＴ／ＮＯ的比例失衡，改善心功能，纠正妊高征的病理生理改变，可作为临床治疗妊高征的药物。
Objective: To observe the effects of nitric oxide (NO) donor nitroglycerin on NO and endothelin (ET) in patients with PIH and to provide a theoretical basis for the treatment of PIH with nitroglycerin. Methods: The patient’s elbow venous blood was drawn 30 minutes before and after treatment. The metabolites of NO in serum were determined by Griess reaction and the content of endothelin in plasma was determined by radioimmunoassay. Cardiac function parameters were also monitored. Results: Nitric glyceride in PIH patients significantly increased NO metabolites (P <0.05), ET significantly decreased (P <0.05), and the ratio of ET to NO metabolites decreased significantly (P <0. 05). CONCLUSION: Nitroglycerin can not only increase the content of NO in blood, but also decrease the content of ET in blood, correct the imbalance of ET / NO ratio, improve cardiac function and correct the pathophysiological changes of PIH, which can be used as clinical medicine for PIH .