论文部分内容阅读
目的 :研究胃肠道间质瘤 (GIST)的临床病理学形态及免疫组化特征。方法 :对 6 9例GIST作了临床病理学的形态观察和免疫组织化学研究。结果 :6 9例GIST中 ,良性 9例 (13.0 % ) ,交界性 2 5例 (36 .2 % ) ,恶性 35例 (5 0 .8% ) ;细胞类型以梭形细胞为主的有 4 6例 ,伴上皮样细胞的有 19例 ,单纯由上皮样细胞组成的有 4例。免疫组织化学特征 :6 5例 (94 .2 % )CD117(C kit)胞质强阳性 ,5 8例 (84 .1% )CD34阳性 ,16例 (2 3.2 % )S 10 0蛋白呈局灶或散在阳性 ;14例 (2 0 .3% )SMA呈局灶阳性 ,仅 3例 (4.3% )desmin阳性。结论 :胃肠道间质瘤恶性发生率较高 (5 0 .8% ) ,有较为独特的组织学形态 ,免疫组织化学CD117敏感性强 ,特异性高 ,是胃肠道间质瘤可靠的标记物 ;CD34表达率较高 ,可作为诊断的参考指标。
Objective: To study the clinicopathological and immunohistochemical features of gastrointestinal stromal tumors (GIST). Methods: Sixty-nine cases of GIST were clinically and pathologically observed and immunohistochemically studied. RESULTS: Among 69 patients with GIST, 9 (13.0%) were benign, 25 (36.2%) were borderline and 35 (58.0%) were malignant. There were 4 6 cases, epithelial-like cells with 19 cases, simple epithelial-like cells in 4 cases. Immunohistochemical characteristics: 65 cases (94.2%) of CD117 (C kit) had strong cytoplasm, 58 (84.1%) were CD34 positive and 16 cases (22.2%) of S 10 0 protein were focal Or scattered positive; 14 cases (20.3%) SMA was focal positive, only 3 cases (4.3%) desmin positive. Conclusions: The high incidence of gastrointestinal stromal tumors (50.8%) has a unique histological morphology. Immunohistochemistry CD117 is highly sensitive and specific and is reliable for gastrointestinal stromal tumors Markers; CD34 expression rate can be used as a diagnostic reference.