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目的 :探讨血管紧张素转换酶抑制剂和醛固酮拮抗剂对实验性高血压大鼠心肌胶原基质重构的干预作用。 方法 :缩窄大鼠腹主动脉复制高血压模型 ,随机分成高血压组 (H组 ) ,安体舒通干预组 (A组 )、培哚普利干预组 (P组 )、培哚普利 +安体舒通干预组 (PA组 )以及对照组 (C组 )。 结果 :与 C组比较 ,术后 2月 H组收缩期左心室压力下降速率 (- dp/ dt)显著降低 ;左心室重量、心肌血管紧张素 和醛固酮含量显著增高 ;H组、P组、A组 3组心肌 型胶原与 型胶原比值 ( / )均显著高于 C组 ,而 PA组 / 显著低于 P组和 A组。 / 与左心室 - dp/ dt显著相关。各药物干预组间血清钾、肌酐测定结果与对照组比较无显著差异。 结论 :培哚普利和安体舒通联用能同时抑制血管紧张素 及醛固酮 ,对实验性高血压大鼠心肌胶原重构的作用优于单用其中任何一种。
Objective: To investigate the effects of angiotensin converting enzyme inhibitors and aldosterone antagonists on myocardial collagen matrix remodeling in experimental hypertensive rats. Methods: The model of hypertensive rat abdominal aorta replication was established and randomly divided into H group (group H), spironolactone group (group A), perindopril group (group P), perindopril + Spironolactone intervention group (PA group) and control group (C group). Results: Compared with group C, the rate of decrease of left ventricular pressure (- dp / dt) in systolic phase of H group was significantly lower than that in group C; the content of left ventricular mass, myocardial angiotensin and aldosterone were significantly increased; The ratios of myocardial collagen to collagen in group 3 were significantly higher than those in group C, while those in group PA were significantly lower than those in group P and group A (P <0.05). / Significantly correlated with left ventricular - dp / dt. The results of serum potassium and creatinine in each intervention group showed no significant difference compared with the control group. CONCLUSION: Perindopril and spironolactone can inhibit both angiotensin and aldosterone at the same time. The effect of perindopril and spironolactone on myocardial remodeling in experimental hypertensive rats is better than that of either alone.