用流式细胞术测定大鼠睾丸生精过程中各种细胞的相对数量及ＤＮＡ含量变化，并取大鼠附睾尾部精子进行扫描电镜观察。发现柳氮磺胺吡啶（ＳＺ）以３５０ｍｇ／ｋｇ·ｄ－１用药２个月后，可轻度抑制睾丸非生精细胞．使增殖活跃细胞ＤＮＡ含量更趋一致。，但不干扰精子的生成，也不会引起精子遗传物质的改变。精子的颈部结构发生明显破坏性改变，断头精子显著增多（Ｐ＜０．０１）。实验结果显示：ＳＺ对睾丸生精过程无明显干扰，但显然能通过某些途径导致精子形态异常。 Flow cytometry was used to determine the relative quantity and DNA content of various cells in the process of testicular spermatogenesis in rats. Scanning electron microscopy was used to observe the spermatogenesis in the rat epididymis tail. Sulfasalazine (SZ) was found to slightly inhibit testicular non-germ cells 2 months after treatment with 350 mg / kg · d-1. So that proliferating active cell DNA content more consistent. , But does not interfere with the formation of sperm, it will not cause changes in sperm genetic material. Sperm structure of the neck of a significant devastating change, a significant increase in sperm count (P <0.01). The experimental results showed that SZ had no obvious interference on testicular spermatogenesis, but obviously it could lead to abnormal sperm morphology through some ways.