【摘 要】
：
Grey matter (GM) alterations may contribute to cognitive decline in individuals with white matter hyper-intensities (WMH) but no consensus has yet emerged.Here,we investigated cortical thickness and grey matter volume in 23 WMH patients with mild cognitiv
【机 构】
：
Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Te
论文部分内容阅读
Grey matter (GM) alterations may contribute to cognitive decline in individuals with white matter hyper-intensities (WMH) but no consensus has yet emerged.Here,we investigated cortical thickness and grey matter volume in 23 WMH patients with mild cognitive impair-ment (WMH-MCI),43 WMH patients without cognitive impairment,and 55 healthy controls.Both WMH groups showed GM atrophy in the bilateral thalamus,fronto-insular cortices,and several parietal-temporal regions,and the WMH-MCI group showed more extensive and severe GM atrophy.The GM atrophy in the thalamus and fronto-insular cortices was associated with cognitive decline in the WMH-MCI patients and may mediate the relationship between WMH and cognition in WMH patients.Further-more,the main results were well replicated in an indepen-dent dataset from the Alzheimer\'s Disease Neuroimaging Initiative database and in other control analyses.These comprehensive results provide robust evidence of specific GM alterations underlying WMH and subsequent cognitive impairment.
其他文献
目的 了解术前肝功能评估方法的临床应用情况及最新进展.方法 对有关术前肝功能评估指标研究的相关文献进行综述并分析.结果 血清学指标可多方面反映肝功能;吲哚菁绿清除试验、Child-Pugh和MELD评分系统可以提高评估肝储备功能的准确性;影像学检查及人工智能(影像组学和深度学习)有助于诊断肝纤维化程度和精准测量功能性肝脏体积.结论 术前评估肝功能的每一种方法均存在一定的局限性,客观而精准地评估肝功能需要结合多种评估指标进行综合分析,从而制定使患者最大获益的个体化诊疗方案.
目的 了解胰腺癌影像学的研究现状及热点.方法 检索Web of Science核心数据库中2001-2020年期间胰腺癌影像学研究的相关文献,采用CiteSpace软件对检索结果进行文献计量学分析.结果 本研究检索到胰腺癌影像学研究领域文献共2 111篇.共被引文献的聚类有19个:血管切除、不可逆电穿孔、自身免疫性胰腺炎、散发胰腺癌、肌少症、胰腺、立体定向体部放疗、转移性胰腺癌、家族性胰腺癌、腹部超声、成纤维细胞、早期诊断、生存时间趋势、影像组学、胰腺炎、吉西他滨、同步放化疗、新辅助化疗、微泡.2016年
目的 探索免疫检查点抑制剂(ICIs)及其联合其他方案治疗晚期肝细胞癌(HCC)患者的疗效、安全性以及需要解决的问题.方法 收集近年来关于晚期HCC患者应用ICIs及其联合治疗的临床试验的相关文献并进行综述.结果 程序性死亡受体1及其配体、细胞毒T淋巴细胞相关抗原4单克隆抗体在晚期HCC患者的临床试验中表现较好,但单药治疗效果局限.双抗体联合治疗以及其与抗血管生成抑制剂、分子靶向药物、局部治疗联合应用方案或许能使患者获得更为显著的治疗效果,尤其是与抗血管生成抑制剂的联合运用.结论 ICIs能显著改善晚期H
Major depressive disorder (MDD),also referred to as depression,is one of the most common psychiatric disorders with a high economic burden.The etiology of depression is still not clear,but it is generally believed that MDD is a multifactorial disease caus
Neurodegeneration,a defining hallmark of Alzheimer\'s disease (AD),features the progressive loss of neuronal structure and functions.Therapeutic approaches to AD show limited efficiency in halting the neurodegeneration to date.Given the lack of neuronal
Dear Editor,rnAcute disseminated encephalomyelitis (ADEM) is an immune-mediated demyelinating disorder characterized by a widespread attack of inflammation in the brain and spinal cord that damages myelin[1].ADEM is life-threatening and among the most fre
Inflammation typically induces pain by producing pro-inflammatory mediators,but increasing evidence also indicates a role for inflammation in the resolution of pain by inducing anti-inflammatory and pro-resolution media-tors[1,2].A recent Nature paper fro
Alzheimer\'s disease (AD),the most common type of dementia,is a devastating neurodegenerative disorder that seriously afflicts millions of patients and their families due to the lack of effective therapeutic drugs and methods.rnElucidating the pathogene
Whether in the West or the East,the connection between the ear and the rest of the body has been explored for a long time.Especially in the past century or more,the relevant theoretical and applied research on the ear has greatly promoted the development
Learning to associate a positive or negative experience with an unrelated cue after the presentation of a reward or a punishment defines associative learning.The ability to form associative memories has been reported in animal species as complex as humans