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宿主自然感染疟原虫后的免疫反应,实际上自从最初发现疟疾病原体后就引起了研究工作者的兴趣。不管受蚊虫感染的数目或感染的次数多少,宿主从未发生一种稳固的无虫免疫性。然而,疟疾感染的严重程度,除随虫种而异之外,在高度疟疾流行区的居民可以由于一生中受到多次感染而显著减弱。另外,还有尚未解释的人宿主对疟疾易感程度的种族差异,西非没有间日疟感染也许就是这个实例。
The host’s natural immune response to Plasmodium in fact has drawn the interest of researchers since the initial discovery of the malaria pathogen. Regardless of the number of mosquito infections or the number of infections, the host never had a robust insect-free immunity. However, the severity of the malaria infection, except for the species of insects, can be significantly reduced by inhabitants of highly malaria-endemic areas due to multiple infections throughout their lives. In addition, there are also ethnic differences in the degree of malaria susceptibility of human hosts that have not yet been explained, and the absence of P. vivax infection in West Africa is perhaps the case.