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[目的]观察自拟胃安煎剂治疗慢性萎缩性胃炎(CAG)癌前病变的临床疗效。[方法]102例患者随机分为2组。治疗组68例,口服胃安煎剂;对照组34例,口服胃苏颗粒和维酶素片。观察2组治疗前、后临床症状,萎缩、肠上皮化生(IM)、异型增生(Dys)的病理及幽门螺杆菌(Hp)的变化。[结果]治疗组临床有效率为91.18%,对照组为76.47%,2组比较差异有统计学意义(P<0.05)。病理检查证实治疗组萎缩、IM和Dys有效率分别为66.18%、67.92%和67.74%;对照组为44.12%、42.31%和29.41%。2组病理疗效差异均有统计学意义(均P<0.05)。治疗组Hp清除率为75.56%,对照组为58.33%(P>0.05)。[结论]胃安煎剂对CAG癌前病变有确切的临床疗效。
[Objective] To observe the curative effect of self-made Weian Decoction on precancerous lesions of chronic atrophic gastritis (CAG). [Methods] 102 patients were randomly divided into two groups. The treatment group of 68 cases, Oral Wei decoction; control group of 34 cases, oral Wei Su particles and vasopressin tablets. The changes of clinical symptoms, atrophy, intestinal metaplasia (IM), dysplasia (Dys) and Helicobacter pylori (Hp) in two groups before and after treatment were observed. [Results] The clinical effective rate was 91.18% in the treatment group and 76.47% in the control group. There was significant difference between the two groups (P <0.05). Pathological examination confirmed that the treatment group atrophy, IM and Dys effective rates were 66.18%, 67.92% and 67.74%; the control group was 44.12%, 42.31% and 29.41%. There were significant differences between the two groups (all P <0.05). Hp clearance rate was 75.56% in the treatment group and 58.33% in the control group (P> 0.05). [Conclusion] Weian decoction has definite clinical effect on CAG precancerous lesions.