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目的：探讨慢性肝病血清白细胞介素－8（IL－8）水平，以分析和研究IL－8与慢性肝病发病以及合并细菌感染时的关系。方法：采用ELISA法检测50例各类慢性肝病患者血清中IL－8水平。结果：血清IL－8水平随着肝脏病变程度加重而递增，慢性乙型肝炎轻度组IL－8水平最低（0．6195±0．3249ng／ml），肝硬变组水平最高（2．4705±2．1243ng／ml）。50例慢性肝病中合并细菌感染19例，血清IL－8水平明显高于未合并细菌感染者，两组比较差异显著。结论：血清IL－8水平的检测可作为慢性肝病病情监测和预后判断的有效指标，尤其对慢性肝病合并细菌感染临床症状不典型，细菌学培养阴性的病人意义更大。
Objective: To investigate the level of serum interleukin-8 (IL-8) in patients with chronic liver disease and to analyze the relationship between IL-8 and chronic liver disease and bacterial infection. Methods: Serum levels of IL-8 in 50 patients with various types of chronic liver diseases were detected by ELISA. Results: Serum levels of IL-8 increased with the severity of liver disease. The levels of IL-8 in mild hepatitis B group were the lowest (0.6195 ± 0.3249ng / ml) and those in cirrhosis group were the highest (2.4705 ± 2.1243 ng / ml). Ninety cases of bacterial infection were found in 50 cases of chronic liver disease, the level of serum IL-8 was significantly higher than those without bacterial infection, the difference was significant between the two groups. Conclusion: The detection of serum IL-8 can be used as an effective indicator for the monitoring and prognosis of chronic liver disease, especially for those patients with atypical clinical symptoms and bacteriological culture of chronic liver disease complicated with bacterial infection.