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目的:探讨不同分期及组织分化的宫颈癌患者HPV病毒载量及宫颈癌不同治疗方案对HPV病毒载量的影响。方法:以2007年1月~2010年1月新疆维吾尔自治区人民医院收治的宫颈鳞癌患者227例为研究对象,根据临床分期分为根治性手术治疗、根治性放疗及根治性放疗联合增敏化疗3组。采集患者入院时及治疗后宫颈分泌物,应用HCⅡ方法检测HPV病毒载量。结果:227例宫颈鳞癌患者中,HPV感染率为99.11%,经治疗后复查HPV感染率为57.26%。多样本均数方差分析结果表明,各个期别宫颈癌的HPV病毒载量差别均有统计学意义(P<0.05),高分化与中分化宫颈鳞癌的HPV病毒载量差别无统计学意义(P>0.05),而中分化与低分化宫颈鳞癌及高分化与低分化宫颈鳞癌的HPV病毒载量差别有统计学意义(P<0.05);根治性手术、根治性放疗、根治性放疗联合增敏化疗对宫颈癌患者治疗后HPV病毒载量的影响有统计学差异(P<0.05)。结论:宫颈癌FIGO分期期别越高、组织分化越低,HPV病毒载量越高,根治性手术治疗及联合放化疗能明显降低宫颈癌患者的HPV病毒载量,HPV病毒载量检测可作为宫颈癌的筛查及病情追踪监测的指标。
OBJECTIVE: To investigate the effect of HPV viral load in cervical cancer patients with different stages and histological differentiation and different treatment options of cervical cancer on HPV viral load. Methods: From January 2007 to January 2010, 227 patients with cervical squamous cell carcinoma admitted to People’s Hospital of Xinjiang Uygur Autonomous Region were divided into radical surgery, radical radiotherapy and radical radiotherapy combined with sensitization chemotherapy 3 groups. Cervical secretions were collected at admission and after treatment, and HCI method was used to detect HPV viral load. Results: Among 227 patients with cervical squamous cell carcinoma, the HPV infection rate was 99.11%. The HPV infection rate after treatment was 57.26%. The analysis of variance of multiple sample mean showed that there was significant difference in HPV viral load between cervical cancer of different stages (P <0.05), but there was no significant difference of HPV viral load between well-differentiated and moderately differentiated cervical squamous cell carcinoma P> 0.05). However, there was significant difference in HPV viral load between moderately differentiated and poorly differentiated cervical squamous cell carcinoma and well differentiated and poorly differentiated cervical squamous cell carcinoma (P <0.05). Radical surgery, radical radiotherapy and radical radiotherapy The effect of combined sensitization chemotherapy on HPV viral load in patients with cervical cancer was statistically significant (P <0.05). Conclusion: The higher the stage of cervical cancer FIGO staging, the lower the tissue differentiation, the higher the HPV viral load, radical surgery and radiotherapy combined with chemotherapy can significantly reduce the HPV viral load in patients with cervical cancer, HPV viral load detection can be used as Cervical cancer screening and monitoring of disease tracking indicators.