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目的:研究马来酸桂哌齐特注射液联合参芎注射液治疗短暂性脑缺血发作的疗效。方法:选择在我院就诊的短暂性脑缺血发作(TIA)患者的临床资料。按照治疗方式不同分为3组:A组给予马来酸桂哌齐特注射液联合参芎注射液治疗;B组给予马来酸桂哌齐特注射液治疗;C组给予参芎注射液治疗。检测血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、全血黏度(高切)、三酰甘油(TG)、胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL),随访观察TIA复发情况并判断疗效。结果:A组患者治疗总体有效率达到96.15%,明显高于B组的78.72%和C组的74.51%;A组患者APTT、PT、TG、TC、HDL、LDL指标均明显改善,B、C两组患者上述指标无明显变化。A组治疗期间发展为脑梗死的例数、半年内复发及发展为脑梗死的例数均明显少于B、C两组。结论:马来酸桂哌齐特注射液和参芎注射液联用可以明显提高TIA治疗的总体有效率,改善血液高凝状态、降低血脂和LDL水平,有利于TIA的治疗和脑梗死的预防。
Objective: To study the curative effect of cinepazide maleate injection combined with Shenxiong injection on transient ischemic attack. Methods: The clinical data of patients with transient ischemic attack (TIA) in our hospital were selected. In accordance with the different treatment groups are divided into three groups: A group was given cinepazide maleate injection combined with Shenxiong injection treatment; B group was given cinepazide maleate injection treatment; C group given Shenxiong injection treatment . Plasma PT, APTT, TC, TG, TC, HDL, and low density Lipoprotein (LDL) were followed up to observe the recurrence of TIA and determine the efficacy. Results: The overall effective rate of treatment in group A was 96.15%, which was significantly higher than 78.72% in group B and 74.51% in group C; APTT, PT, TG, TC, HDL and LDL were significantly improved in group A, B and C The two groups of patients no significant change in the above indicators. A group of patients developed during the treatment of cerebral infarction, the number of cases of recurrent and develop within six months of cerebral infarction were significantly less than B, C two groups. Conclusion: Cinepazide maleate injection and Shenxiong injection can significantly improve the overall efficiency of TIA treatment, improve blood hypercoagulability, lower blood lipids and LDL levels, is conducive to the treatment of TIA and prevention of cerebral infarction .