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目的探讨恶性肿瘤特异性标志物检测对肺癌早期诊断的临床价值。方法选择平顶山市第一人民医院收治的术后病理学确诊为肺癌和肺部良性疾病患者各6 7例,分别定义为研究1组、研究2组。选择同期健康体检人群6 7例作为对照组。对3组研究对象的神经元特异性烯醇化酶、癌胚抗原、细胞角蛋白21-1、鳞癌相关抗原水平进行测定,并对比测定结果。结果研究1组研究对象的神经元特异性烯醇化酶、癌胚抗原、细胞角蛋白21-1以及鳞癌相关抗原检测结果,均较研究2组和对照组高,差异有统计学意义(P<0.05);研究2组研究对象的神经元特异性烯醇化酶、癌胚抗原、细胞角蛋白21-1、鳞癌相关抗原水平明显高于对照组,差异有统计学意义(P<0.05)。结论患有肺癌的患者神经元特异性烯醇化酶、癌胚抗原、细胞角蛋白21-1、鳞癌相关抗原等恶性肿瘤特异性指标水平明显高于健康人群和肺部良性疾病患者,可以作为临床对肺癌实施诊断的客观参考指标。
Objective To investigate the clinical value of detection of malignant tumor-specific markers in the early diagnosis of lung cancer. Methods Sixty-seven patients with lung cancer and benign lung diseases diagnosed by the First People’s Hospital of Pingdingshan City were selected as the study group and two groups respectively. Select the same period health examination population 67 cases as a control group. The levels of neuron-specific enolase, carcinoembryonic antigen, cytokeratin 21-1, squamous cell carcinoma-associated antigen in three groups of subjects were measured and the results were compared. Results The neuron-specific enolase, carcinoembryonic antigen, cytokeratin 21-1, and squamous cell carcinoma-associated antigen in the study group were higher than those in the two study groups and the control group, with significant difference (P <0.05). The levels of neuron-specific enolase, carcinoembryonic antigen, cytokeratin 21-1 and squamous cell carcinoma-associated antigen in the two study groups were significantly higher than those in the control group (P <0.05) . Conclusions Patients with lung cancer have significantly higher specific markers of malignant tumors such as neuron specific enolase, carcinoembryonic antigen, cytokeratin 21-1 and squamous cell carcinoma-associated antigen as compared with healthy people and patients with benign lung disease, Clinical diagnosis of lung cancer objective reference indicators.