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Objective To investigate the inhibition of low dose radiation(LDR) on S180 sarcomas and its modulation of MMP-2 and TIMP-2 in mice.Methods S180 subcutaneously implanted tumor model mice were randomly divided into two groups: control(N) and low dose radiation(LDR) groups. N mice were sacrificed after 12 h, whereas LDR mice were sacrificed after 12(LDR-12 h), 24(LDR-24 h), 48(LDR-48 h), and 72(LDR-72 h) h. Thereafter, we measured the tumor volumes. Histopathology was performed, and P-V immunohistochemistry was applied to assess MMP-2 and TIMP-2 expression.Results Compared with the control group, the tumor growth was significantly inhibited in the LDR groups(P < 0.05). MMP-2 expression was considerably reduced in LDR-24h(P < 0.05) and LDR-48h(P < 0.05), whereas the change of TIMP-2 was not obvious in the LDR groups(P > 0.05) in contrast to that of the control group.Conclusion LDR can effectively suppress the growth of S180 implanted tumors by reducing MMP-2, which is associated with invasion and metastasis.
Objective To investigate the inhibition of low dose radiation (LDR) on S180 sarcomas and its modulation of MMP-2 and TIMP-2 in mice. Methods S180 subcutaneously implanted tumor model mice were randomly divided into two groups: control (N) and low dose radiation (LDR) groups. N mice were sacrificed after 12 h, but LDR mice were sacrificed after 12 (LDR-12 h), 24 (LDR- 24 h), 48 (LDR- 48 h), and 72 Histopathology was performed, and PV immunohistochemistry was applied to assess MMP-2 and TIMP-2 expression. Results Compared with the control group, the tumor growth was significantly inhibited in the LDR groups ( P <0.05). The change of TIMP-2 was significantly reduced in LDR-24h (P <0.05) and LDR-48h (P <0.05) in contrast to that of the control group. Conflux of LDR can effectively suppress the growth of S180 implanted tumors by reducing MMP-2, which is associated with invas ion and metastasis.