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文章改进了盐酸托莫西汀(R-(-)-N-甲基-3-苯基-3-(2-甲基苯氧基)丙胺盐酸盐)的合成方法。以N-甲基-3-苯基-3-羟基丙胺作为起始原料,通过保护基反应、取代反应、脱保护反应、化学拆分、成盐5步反应,合成了目标化合物,并经IR、HNMR等对其结构进行了表征。本合成反应条件温和,原料易得,操作简便,适合于工业化生产。反应总收率为41.3%。
The article improved the method for the synthesis of tomoxetine hydrochloride (R - (-) - N-methyl-3-phenyl-3- (2-methylphenoxy) propylamine hydrochloride). Using N-methyl-3-phenyl-3-hydroxypropylamine as the starting material, the target compound was synthesized by the reaction of protecting group, substitution reaction, deprotection reaction, chemical resolution and salt formation. , HNMR and other structures were characterized. The synthesis reaction conditions are mild, raw materials are easy to obtain, easy to operate and suitable for industrialized production. The total reaction yield was 41.3%.