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目的研究支气管动脉灌注化疗(BAI)结合胸廓内动脉灌注化疗(IAI)联合CT导引经皮瘤体内注射化疗药物(PC I)治疗中晚期原发性肺癌的可行性及临床价值。方法治疗组30例Ⅲ、Ⅳ期原发性肺癌,行BAI+IAI+PC I;对照组28例Ⅲ、Ⅳ期原发性肺癌,行BAI+PC I。通过CT、生活质量及生存期等指标观察疗效。结果治疗组近期有效率73.3%,高于对照组46.4%(Ρ<0.05);且生活质量、生存期均有明显提高。结论BAI结合IAI联合CT导引经皮瘤内注射是一种安全有效的治疗方法,能明显改善中晚期原发性肺癌患者的生活质量,提高近期疗效,延长生存期。
Objective To study the feasibility and clinical value of bronchial artery infusion chemotherapy (BAI) combined with intra-thoracic arterial infusion chemotherapy (IAI) and CT-guided percutaneous in vivo chemotherapy (PCI) in the treatment of advanced primary lung cancer. Methods BAI + IAI + PCI was performed in 30 patients with stage Ⅲ and Ⅳ primary lung cancer and 28 patients with stage Ⅲ and Ⅳ primary lung cancer in control group. Through CT, quality of life and survival indicators such as observation of efficacy. Results The treatment group was 73.3% efficient, 46.4% higher than the control group (P <0.05); and the quality of life and survival were significantly improved. Conclusion BAI combined with IAI and CT guided percutaneous intratumoral injection is a safe and effective treatment, which can significantly improve the quality of life of patients with advanced primary lung cancer, improve the short-term efficacy and prolong survival.