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背景:血管紧张素转换酶抑制剂和钙离子拮抗剂对原发性高血压内皮受损的保护作用的研究已很深入,传统祖国医药在这方面的研究愈发显示出其重要地位。目的:观察红花注射液对原发性高血压血管内皮的保护作用。设计:随机开放实验方法进行前瞻性病例对照/随访研究。地点、对象和干预:在上海交通大学附属第六人民医院住院及门诊患者中,根据1999WHO/ISH高血压指南和中国高血压防治指南的诊断标准,选取70例原发性高血压(2～3级,极高危)患者,随机分为红花注射液组24例,丹参注射液组23例,对照组23例。红花注射液组予红花注射液20mL静脉滴注。丹参注射液组予丹参注射液20mL静脉滴注。对照组只予常规降压药治疗。观察3组研究对象用药前后血管收缩因子、血管舒张因子的变化。主要观察指标:3组患者用药2周前后血管收缩因子(内皮素、血栓素2)和血管舒张因子犤一氧化氮、6-酮前列腺素-F1α(6-keton-prostaglandinF1α,6-Keto-PGF1α)犦的变化。结果:三组患者用药前血浆内皮素、一氧化氮、血栓素2、6-酮前列腺素-F1α(6-keton-prostaglandinF1α,6-Keto-PGF1α)的检测结果差异无显著性意义(P>0.05)。红花治疗组在治疗后内皮素明显下降,与对照组和丹参组有显著差别(P<0.05);治疗后红花组与丹参组血栓素犤(307.9±12.9),(27
BACKGROUND: The research on the protective effect of angiotensin converting enzyme inhibitors and calcium ion antagonists on the damage of endothelial dysfunction in essential hypertension has been deeply studied. The study of traditional Chinese medicine in this field has increasingly shown its importance. Objective: To observe the protective effects of safflower injection on vascular endothelial cells in patients with essential hypertension. DESIGN: Randomized open-label experimental prospective case-control / follow-up study. Location, Subjects and Interventions: According to the diagnostic criteria of 1999 WHO / ISH Hypertension Guideline and Chinese Hypertension Prevention Guideline, 70 patients with primary hypertension (2-3 patients) were selected as inpatients and outpatients in the Sixth People’s Hospital affiliated to Shanghai Jiaotong University. Grade, very high risk) patients were randomly divided into safflower injection group 24 cases, Salvia injection group 23 cases, control group 23 cases. Safflower injection group safflower injection 20mL intravenous infusion. Danshen injection Danshen injection 20mL intravenous drip. The control group only conventional antihypertensive drug treatment. The changes of vasoconstrictor and vasodilator in the three groups were observed before and after treatment. MAIN OUTCOME MEASURES: Vasoconstrictive factors (endothelin, thromboxane 2) and vasodilator nitric oxide, 6-keto-prostaglandinF1α (6-Keto-PGF1α ) 犦 changes. Results: There was no significant difference in the levels of plasma endothelin, nitric oxide and 6-keto-prostaglandin F1alpha (6-Keto-PGF1α) in three groups before treatment (P> 0.05). Compared with the control group and the Salvia miltiorrhiza group, the endothelin in the safflower treatment group obviously decreased after treatment (P <0.05), and the levels of thromboxane (307.9 ± 12.9), (27