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[目的]研究血管乏氧诱导因子-1α(hypoxia induced factor-1α,HIF-1α)在肝细胞癌组织中表达及其在判断预后中的价值。[方法]对随访的60例原发性肝癌患者的临床资料进行回顾性分析,通过免疫组化方法检测HIF-1α在癌组织中的表达情况。[结果]HIF-1α阳性表达率为53.3%。HIF-1α与细胞分化程度具有相关性。HIF-1α高表达组和低表达组患者的1、3、5年无瘤生存率分别为57.1%,14.3%,0和84.9%,50.7%,23.3%。高表达患者无瘤生存期明显低于低表达患者(P=0.004)。[结论]HIF-1α高表达肝细胞癌生存期低,HIF-1α是肝细胞癌切除术后预后判定的预测因子。
[Objective] To investigate the expression of hypoxia induced factor-1α (HIF-1α) in hepatocellular carcinoma (HCC) and its value in prognosis. [Methods] The clinical data of 60 patients with primary liver cancer who were followed up were retrospectively analyzed. The expression of HIF-1α in cancer tissues was detected by immunohistochemistry. [Results] The positive rate of HIF-1α expression was 53.3%. HIF-1α and cell differentiation have a correlation. The 1, 3, 5 year disease-free survival rates were 57.1%, 14.3%, 0 and 84.9%, 50.7% and 23.3% in patients with HIF-1α overexpression and low expression respectively. Patients with high expression of tumor-free survival was significantly lower than those with low expression (P = 0.004). [Conclusion] The high expression of HIF-1α in hepatocellular carcinoma has a low survival rate, and HIF-1α is a predictor of the prognosis of hepatocellular carcinoma after resection.