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以N-丁基-N-(4-羟丁基)亚硝基胺(BBN)为致癌剂诱发Wistar大鼠膀胱肿瘤,并用维甲类化合物13-顺-视黄酸进行化学预防。实验结果表明,13-顺-视黄酸对BBN诱发的大鼠膀胱肿瘤具有明显的抑制作用。抑制组膀胱肿瘤发生率(55.6％/100％),发瘤数目(平均1.44个/9.67个),肿瘤大小(平均直径和4.82mm/19.00mm)及病理级别(评分1.89分/3.22分)均明显低于对照组。两组36只实验大鼠中29只发生膀胱肿瘤,发瘤率为80.6％。而肝肾等其它器官末见肿瘤发生。85.7％的膀胱肿瘤发生癌变,67.9％为浸润癌。13-顺-视黄酸无明显肝、肾毒性。
Wistar rat bladder tumors were induced with N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) as carcinogen and chemoprevention with retinoid 13-cis retinoic acid. The experimental results show that 13-cis retinoic acid has a significant inhibitory effect on BBN-induced bladder cancer in rats. The incidence of bladder tumor in the suppression group (55.6%/100%), the number of tumors (mean 1.44/9.67), tumor size (mean diameter and 4.82mm/19.00mm), and pathological grade (grade 1.89/3.22) Significantly lower than the control group. Twenty-nine of the 36 experimental rats in the two groups developed bladder tumors with a tumor rate of 80.6%. The liver and kidney and other organs see the tumor at the end. 85.7% of bladder tumours were cancerous and 67.9% were invasive. 13-cis retinoic acid has no obvious liver and kidney toxicity.