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目的:分析氨茶碱联合全程指导综合康复训练治疗稳定期慢性阻塞性肺疾病(COPD)的近期疗效。方法:选择确诊的稳定期COPD患者72例,随机均分为研究组和对照组。研究组给予口服小剂量氨茶碱联合全程指导综合康复训练,对照组仅口服小剂量氨茶碱。记录治疗前和治疗6个月后患者呼吸困难程度、运动能力、日常生活活动(ADL)能力、血气和肺功能变化。比较两组患者相关参数差异。结果:与治疗前相比,研究组和对照组治疗后ADL能力评分、PaO2、6MWT、FEV1/FVC、FEV1%预计值和MVV明显增加,RV、MRC评分和PaCO2明显降低(P<0.05);治疗组治疗后的ADL能力评分、PaO2、6MWT、FEV1/FVC、FEV1%预计值和MVV显著高于对照组,RV、MRC评分和PaCO2显著低于对照组(P<0.05)。结论:小剂量氨茶碱联合全程指导综合康复训练是一种有效治疗稳定期COPD的方法。
Objective: To analyze the short-term curative effect of aminophylline combined with comprehensive rehabilitation training in the treatment of stable chronic obstructive pulmonary disease (COPD). Methods: Seventy-two patients with stable COPD were selected and randomly divided into study group and control group. The study group given a small dose of oral aminophylline combined with full guidance of comprehensive rehabilitation training, the control group only oral dose of aminophylline. The degree of dyspnea, motor ability, activities of daily living (ADL), changes of blood gas and lung function were recorded before treatment and 6 months after treatment. The differences of the related parameters between the two groups were compared. Results: After treatment, ADL score, PaO2, 6MWT, FEV1 / FVC, FEV1% predictive value and MVV in study group and control group were significantly increased, RV, MRC score and PaCO2 were significantly decreased (P <0.05) ADL score, PaO2, 6MWT, FEV1 / FVC, FEV1% predicted value and MVV in the treatment group were significantly higher than those in the control group, RV, MRC score and PaCO2 were significantly lower than those in the control group (P <0.05). Conclusion: A small dose of aminophylline combined with full guidance of comprehensive rehabilitation training is an effective treatment of stable COPD.