目的 :研究幽门螺杆菌 (Hp)感染与口腔疾病的关系。方法 :通过PCR方法检测口腔疾病患者和正常人牙菌斑中Hp情况。结果 :牙菌斑Hp与复发性口腔溃疡 (ROU)高度相关 (P <0 .0 1) ;与口腔扁平苔癣 (OLP)、牙周炎、干槽症 (DS)、龋病呈显著性相关 (P <0 .0 5 ) ;牙周炎、龋病严重程度和牙菌斑取样部位与Hp检出阳性率亦有关联 (P <0 .0 5 )。结论 :牙菌斑Hp感染与口腔疾病发病明显相关 Objective: To study the relationship between Helicobacter pylori (Hp) infection and oral diseases. Methods: Hp was detected in dental plaque of patients with oral diseases and normal subjects by PCR. Results: The dental plaque Hp was highly correlated with recurrent oral ulcer (ROU) (P <0.01), and was significantly different from oral lichen planus (OLP), periodontitis, dry socket (DS) (P <0.05). The severity of periodontitis and dental caries as well as the location of plaque sampling sites were also correlated with the positive rate of Hp detection (P <0.05). Conclusion: Hp infection of dental plaque is obviously related to the onset of oral diseases