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目的 :探讨干扰素α- 1b(赛若金 )联合大黄虫丸治疗慢性乙型肝炎抗病毒、抗肝纤维化的疗效以及安全性。方法 :观察组 (赛若金和大黄虫丸 ) 6 0例在护肝基础上 ,同时应用赛若金 3× 10 6 u,肌注 ,1次 / d,连用 2周 ,改为 1次 / 2 d;大黄虫丸 ,3g/次 ,3次 / d,口服。对照组 6 0例一般护肝治疗。均 3个月 1疗程 ,连用 2疗程。结果 :观察组在疗程结束时HBe Ag及 HBV- DNA阴转率为 6 3.3%和 6 8.3% ,与对照组比较 ,差异有非常显著性意义 (P<0 .0 1) ;观察组治疗后透明质酸和球蛋白水平明显下降 ,白蛋白升高 ,与治疗前比较 ,差异有显著性意义 ,对照组治疗前后差异无显著性意义。结论 :赛若金联合大黄虫丸治疗慢性乙型肝炎均能增强抗病毒、抗肝纤维化的作用 ,且安全性好 ,值得临床推广
Objective: To investigate the efficacy and safety of interferon alfa-1b combined with rhubarb in the treatment of chronic hepatitis B antiviral and anti-liver fibrosis. Methods: 60 cases of observation group (Sauruo gold and rhubarb Zhechong pills) on the basis of liver protection, while the sausage gold 3 × 10 6 u, intramuscular injection, 1 / d, once every 2 weeks, changed to 1 / 2 d; rhubarb Zhechong pill, 3g / times, 3 times / d, orally. Control group 60 cases of general liver protection. All 3 months 1 course of treatment, used in conjunction with 2 courses. Results: The negative conversion rates of HBe Ag and HBV DNA in the observation group were 63.3% and 63.3% at the end of the treatment course, respectively, which were significantly different from those in the control group (P0.01) Hyaluronic acid and globulin levels decreased significantly, albumin increased, compared with before treatment, the difference was significant, the difference between the control group before and after treatment was not significant. Conclusion: Saurin combined with rhubarb Zhechong pill in the treatment of chronic hepatitis B can enhance the anti-virus, anti-liver fibrosis, and the safety is good, worthy of clinical promotion