应用糖皮质激素可引起眼压升高 ,它与原发性开角型青光眼关系密切。糖皮质激素对小梁网的作用可作为一个良好模型用于研究青光眼的发病机制。糖皮质激素对小梁网的作用是多方面的 ,它包括细胞外基质、细胞膜、细胞骨架及细胞核的多重变化。糖皮质激素受体的分子机制的新发现有助于从受体角度了解青光眼的发病机制 Application of glucocorticoid can cause elevated intraocular pressure, which is closely related with primary open-angle glaucoma. The effect of glucocorticoids on trabecular meshwork can be used as a good model for studying the pathogenesis of glaucoma. The effects of glucocorticoids on the trabecular meshwork are numerous and include multiple changes in the extracellular matrix, the cell membrane, the cytoskeleton, and the nucleus. New Discovery of the Molecular Mechanism of Glucocorticoid Receptor Helps to Understand the Pathogenesis of Glaucoma from the Perspective of Receptors