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群体反应性抗体（PRA）的测定对了解受者体内抗HLA抗体的水平及致敏状态，预防超急和加速排斥反应的发生具有重要意义，其敏感性明显高于供受者交叉配型试验（CDC），高PRA（阳性率≥50％）与严重排斥反应及移植物存活率下降密切相关。血浆置换（PE）能有效清除PRA阳性受者血清中的抗体，避免超意和加速排斥反应的发生，但良好的HLA配型对提高PRA阳性患者的手术成功率和移植物存活率更重要。通过随机多次淋巴细胞毒性试验（RPLT）与PRA的对比研究表明，RPLT是一项简单、可靠、便于推广的预测受者致敏状态的方法。
The determination of PRA is of great significance to understand the level of anti-HLA antibodies and the state of sensitization in the recipient, and to prevent the occurrence of hyperacute and accelerated rejection, and its sensitivity is significantly higher than that of donor cross-matching test (CDC) and high PRA (positive rate≥50%) are closely related to severe rejection and decreased graft survival. Plasma exchange (PE) is effective in removing serum from PRA-positive recipients and avoids over- and exacerbation of rejection. However, good HLA typing is more important for improving surgical success and graft survival in PRA-positive patients. RPLT is a simple, reliable and convenient method to predict the sensitization state of recipients by comparing with randomized multiple lymphocyte toxicity test (RPLT) and PRA.