有报道称马兜铃酸有诱变作用和毒性,但迄今尚未在弓形马兜铃Aristolochia arcu-ata Masters中发现该成分。作者研究了该植物中新木脂素成分talaumidin对培养的大鼠皮质神经元的营养作用。 18d大的SD胎鼠脑皮质神经元培养1d后,培养液更换为含有多种浓度的talau-midin的营养液继续培养3d,用抗-微小管相关蛋白(MAP)2染色法评价试药对神经元形态学的作用。结果显示,用10μmol/L talau- Aristolochic acid has been reported to have mutagenicity and toxicity, but it has not been found in Aristolochia arcu-ata Masters. The authors studied the nutritional effects of talomidin, a novel lignan component, on cultured rat cortical neurons. After 1d of culture of neurons in 18d SD rat fetal rat brain, the medium was replaced with nutrient solution containing various concentrations of talau-midin for 3 days. The anti-microtubule-associated protein (MAP) 2 staining method was used to evaluate the pair of test drugs. The role of neuronal morphology. The results showed that with 10μmol/L talau-