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通过动物实验观察丹参对急性肝损害的保护作用及丹参对炎性介质血栓素（TXA2）、前列环素（PGI2）的影响。结果显示：损伤组大鼠血浆血栓素B2（TXB2）为（782．73±577．16）ng／L，而实验组为（34．93±272．49）ng／L，显著低于损伤组（P＜0．05）。两组血浆6－酮－前列腺素F1a分别为（23．27±13.45）和（26.67±12.52）ng／L，差异不显著。血浆TXB2与脂质过氧化物水平呈正相关（r=0.668，P＜0．01）。实验组血谷丙转氨酶、谷草转氨酶活性低于损伤组，肝脏病理损害减轻。结果提示：丹参可抑制缩血管介质TXA2的增高，对急性肝损害有保护作用。
The effects of salvia miltiorrhiza on acute hepatic injury and the effect of salvia miltiorrhiza on thromboxane (TXA2) and prostacyclin (PGI2) were investigated through animal experiments. The results showed that the plasma thromboxane B2 (TXB2) was (782.73±577.16) ng/L in the injured group and (34.93±272.49) ng/L in the experimental group, which was significantly lower than the injury group. (P<0.05). Plasma levels of 6-keto-prostaglandin F1a in the two groups were (23.27±13.45) and (26.67±12.52) ng/L, respectively, with no significant difference. There was a positive correlation between plasma TXB2 and lipid peroxide levels (r=0.668, P<0.01). The activities of serum alanine aminotransferase and aspartate aminotransferase in the experimental group were lower than those in the injured group, and the pathological damage in the liver was reduced. The results suggest that Salvia miltiorrhiza can inhibit the increase of TXA2, a vasoconstrictor medium, and has a protective effect on acute liver damage.