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将“自杀基因”导入肿瘤细胞而将前体药物在肿瘤细胞内代谢为毒性产物进而杀伤肿瘤细胞的“自杀基因”疗法是肿瘤基因治疗中引人注目的途径之一。细胞的自杀机制是设计该疗法的基础,“自杀基因”有多种,包括tk及CD等,将肿瘤细胞特异的调控元件或转录元件与自杀基因相结合可使“自杀基因”特异地在肿瘤细胞中表达,从而选择性地杀伤肿瘤细胞。美国NIH已批准HSV-tk基因转染疗法用于脑瘤等的临床试治。
The introduction of “suicide gene” into tumor cells and metabolizing the prodrug into toxic products in tumor cells to kill tumor cells is one of the most attractive approaches to tumor gene therapy. The suicide mechanism of cells is the basis for the design of the therapy. There are many types of “suicide genes” including tk and CD. Combining tumor cell-specific regulatory elements or transcription elements with suicide genes can make “suicide genes” specific to tumors. Expressed in cells to selectively kill tumor cells. The United States NIH has approved HSV-tk gene transfection therapy for clinical trials such as brain tumors.