论文部分内容阅读
利用酶催化反应来制备手性的药物中间体是目前药物研究领域的一个热点。本文按照酶催化反应类型(还原、动力学拆分、水解、氧化)通过具体实例综述了近年来酶催化反应在抗高血压药物手性中间体合成中的应用,主要强调了其酶催化的立体选择性。
The use of enzyme-catalyzed reactions to prepare chiral drug intermediates is currently a hot area in the field of pharmaceutical research. This article reviews the application of enzyme-catalyzed reactions in the synthesis of antihypertensive drug chiral intermediates in recent years according to the types of enzymatic reactions (reduction, kinetic resolution, hydrolysis, oxidation). The main emphasis is on the enzyme-catalyzed stereochemistry Selective.