论文部分内容阅读
以丁二酸酯为间隔臂制备了甘草次酸修饰壳聚糖的肝靶向药物载体材料(mGA-suc-CTS),通过IR,NMR及元素分析对产物的结构及取代度进行了表征;以BSA为药物模型,离子交联法制备了载药粒子,初步研究了其体外释放性能.结果表明,载体材料中甘草次酸的含量可通过反应温度及投料比进行调控,最高取代度可达5.19%;纳米粒子对BSA的负载量为26.3%,包封率为81.5%;体外释放表明,生理条件下(pH7.4)缓释可达11天.
The glycyrrhetinic acid modified chitosan liver targeting drug carrier material (mGA-suc-CTS) was prepared by using succinate as spacer. The structure and degree of substitution of the product were characterized by IR, NMR and elemental analysis. The drug-loaded particles were prepared by ion-crosslinking method using BSA as the drug model and the in vitro release properties were studied.The results showed that the content of glycyrrhetinic acid in the carrier material can be controlled by the reaction temperature and the feed ratio, the highest degree of substitution 5.19%. The loading of nanoparticles on BSA was 26.3% and the entrapment efficiency was 81.5%. The in vitro release showed that the sustained release of BSA under physiological conditions (pH7.4) was up to 11 days.