【摘 要】
：
目的:比较米氮平和氯米帕明治疗对抑郁症患者生活质量的影响.方法:将符合CCMD-3诊断标准的抑郁症患者48例随机分组,分别使用米氮平(23例)、氯米帕明(25例)治疗,随访6个月.以
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目的:比较米氮平和氯米帕明治疗对抑郁症患者生活质量的影响.方法:将符合CCMD-3诊断标准的抑郁症患者48例随机分组,分别使用米氮平(23例)、氯米帕明(25例)治疗,随访6个月.以汉密顿抑郁量表(HAMD)评定疗效,以精神药物不良反应量表(TESS)评定不良反应,以生活质量综合评定问卷(GQOLI)评定生活质量.结果:6个月后,米氮平组HAMD评分(9.4±3.4)低于氯米帕明组(14.2±3.5,t=3.42,P＜0.05);GQOLI评分(196.2±10.1)高于氯米帕明组(170.7±19.9,t=7.62,P＜0.01);不良反应较氯米帕明组少.治疗前后相比,米氮平组患者的GQOLI总分升高(165.2±21.9,196.2±10.1,P＜0.01).氯米帕明组患者GQOLI总分变化(166.4±19.6,170.7±19.9)不显著(P＞0.05).结论:米氮平治疗抑郁症疗效好,不良反应少,对患者生活质量的改善作用优于氯米帕明,有利于患者重返社会.
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