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目的 探讨硫酸镁预处理对依托咪酯引起肌阵挛的影响.方法 50例全麻下手术患者随机双盲均分入两组,诱导时先静注硫酸镁60 nag(M组)或生理盐水(S组),3 min后静注依托咪酯0.3 mg/kg.评估肌阵挛和疼痛发生情况,记录血流动力学的变化和BIS.结果 M组肌阵挛发生率显著低于S组(24%vs.68%).M组注射痛发生率显著低于S组(8%vs.16%).S组患者注射依托咪酯2 min后发生重度肌阵挛时的BIS值明显升高于无肌阵挛者[(51.8±7.2)vs.(39.5±6.2)](P0.05).结论 依托咪酯诱导前使用小剂量硫酸镁可以显著降低肌阵挛和疼痛的发生率.“,”Objective To study the effects of magnesium sulfate preinjection on etomidate-induced myoclonus and pain during anesthesia induction. Methods Fifty patients undergoing general anesthesia were devided ramdomly and blindly into two groups with 25 cases each. Magnesium sulfate 60 rag(group M) or normal saline(group S) was injected intravenously, which was followed by etomidate 0. 3 mg/kg for anesthesia induction 3 min later. Myoclonus and pain were observed, BIS and hemodinamics were recorded. Results The incidences of myoclonus and pain were lower in group M than those in group S[(24% vs. 68%) and (8% vs. 16%)](P<0. 01 and P<0. 05). BIS value was higher in the cases with severe myoclonus than those without in group S [(51.8±7. 2) vs. (39. 5± 6. 2)](P<0. 05). The incidence of myoclonus was not associated with gender and age. Thre was no significant defference in hemodynamics between two groups during anesthesia induction. Conclussion Preinjection of magnesium sulfate can effectively reduce etomidate-induced myoclonus and pain during anesthesia induction.