在恶性肿瘤的发生发展与免疫治疗中,免疫逃逸发挥了非常重要的作用。尽管目前研究表明已经有多种肿瘤特异性肿瘤相关抗原被分离鉴定,免疫反应的基本信号通路也比较清楚,肿瘤免疫反应的基本条件已经具备,但肿瘤仍然可以逃避机体的免疫反应,主要原因是肿瘤在与机体的对抗和选择过 In the occurrence and development of malignant tumors and immunotherapy, immune escape has played a very important role. Although the current studies show that there are many tumor-specific tumor-associated antigens have been isolated and identified, the basic immune signaling pathway is clear, the basic conditions for tumor immune response are available, but the tumor can still escape the body’s immune response, mainly due to Tumor in the confrontation with the body and choose too