大量超剂量的扑热息痛能引起不可逆的肝细胞损害和死亡。扑热息痛中毒的特异之处在于它的毒性作用要在服药后数天才能表现。当服药后人体内血药浓度达到最高点时,通常它的毒性作用也发挥得最大。除了有象氢氧化钠那样的强碱或强酸引起肝脏结构损害而致的组织损害以外,当药物被排泻后它的毒性作用也下降。即使服用很高剂最,扑热息痛最初也不是很毒的,仅在使用数天后它所引起的肝脏毒性才能见到。这是因为造成损害作用的毒性物质并不是扑热息痛本身,而是它的一种代谢物。扑热息痛在肝脏的代谢要通过一系列不同的过程,因此,一些不同 A large number of overdose of paracetamol can cause irreversible liver cell damage and death. The peculiarities of paracetamol poisoning are that its toxic effects must be demonstrated within a few days of taking the medication. When taking the drug after the human plasma concentration reaches its highest point, usually its toxic effects also play the greatest. In addition to the tissue damage caused by the structural damage of the liver caused by strong bases such as sodium hydroxide or strong acids, its toxicity is also reduced when the drug is excreted. Paracetamol is not very toxic at first, even if it is administered in high doses, and the liver toxicity it causes can only be seen after a few days of use. This is because the toxic substance that caused the damage is not paracetamol itself but a metabolite of it. Paracetamol in the liver metabolism through a series of different processes, therefore, some differences