已知,有几种非结合型药物以及甾体激素能通过血管壁进入唾液中。用放射免疫分析法可以测定唾液中甾体激素的浓度,因此,测定唾液中甾体激素的浓度以评价内分泌机能的可能临床意义已引起人们极大的兴趣。测定尿中甾体激素由于收集尿液的困难而受限,测定血中激素需做静脉穿刺,紧张可能会影响结果。相比之下,在很短的间隔内可很容易和频繁地采取唾液而易被受试者接受。最近报 It is known that several non-binding drugs and steroid hormones enter the saliva through the blood vessel wall. Radioimmunoassay can determine the concentration of steroid hormones in saliva, therefore, the determination of the concentration of steroids in saliva to evaluate the possible clinical significance of endocrine function has aroused great interest. Determination of urinary steroid hormone due to the difficulties of collecting urine is limited to determine the blood hormone need to do venipuncture, tension may affect the results. In contrast, saliva can be easily and frequently taken at short intervals and easily accepted by the subject. Recently reported