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目的:探讨急性冠脉综合征患者(ACS)血清总胆红素(TBIL)、尿酸(UA)及纤维蛋白原(FIB)含量变化及其与冠脉病变程度(冠脉病变积分)的相关性。方法:将232例ACS患者分为2组,其中急性心肌梗死(AMI)患者102例,不稳定性心绞痛(UAP)患者130例,同时选择冠状动脉造影(CAG)正常患者50例作为对照组,分别测定各组TBIL、UA及FIB的含量,并与冠脉病变积分做相关性分析。结果:ACS患者UA及FIB含量均高于对照组,而TBIL含量低于对照组(P<0.01)。UA、FIB与冠脉病变积分呈正相关,TBIL与冠脉病变积分呈负相关。结论:UA和FIB的升高及TBIL的降低与ACS发生和冠脉病变的严重程度有一定的关系。
Objective: To investigate the changes of serum total bilirubin (TBIL), uric acid (UA) and fibrinogen (FIB) in patients with acute coronary syndrome (ACS) and its correlation with the severity of coronary artery disease . Methods: A total of 232 ACS patients were divided into two groups: 102 patients with acute myocardial infarction (AMI), 130 patients with unstable angina pectoris (UAP) and 50 normal coronary angiography (CAG) patients as control group, The contents of TBIL, UA and FIB in each group were determined, and their correlations with coronary lesion scores were analyzed. Results: The contents of UA and FIB in patients with ACS were higher than those in control group, while the levels of TBIL in patients with ACS were lower than those in control group (P <0.01). UA, FIB and coronary artery disease score was positively correlated, TBIL and coronary artery disease score was negatively correlated. Conclusion: The increase of UA and FIB and the decrease of TBIL have a certain relationship with the occurrence of ACS and the severity of coronary artery disease.