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目的:评价环磷酰胺与泼尼松联用对系统性红斑狼疮(SLE)患者外周血T淋巴细胞亚群的作用。方法:选取2014年1月—2015年1月期间收治的SLE患者115例,将其分为对照组(55例)和观察组(60例);对照组患者均给予常规治疗,观察组患者在对照组治疗的基础上均给予环磷酰胺与泼尼松联用治疗,采用流式细胞仪检测患者治疗前后外周血淋巴细胞亚群的变化情况。结果:治疗后观察组患者的外周血T淋巴细胞亚群,即CD3(+)、CD4(+)值以及CD4(+)/CD8(+)比值明显高于对照组(P<0.05);观察组患者的外周血CD8(+)T淋巴细胞值明显低于对照组(P<0.05);观察组患者的外周血NK细胞数量明显高于对照组(P<0.05);B淋巴细胞数量明显低于对照组(P<0.05);治疗后观察组患者SLE疾病活动度按文献[6]方法评分,其值明显低于对照组(P<0.05);两组患者用药后不良反应发生率经比较其差异无统计学意义(P>0.05)。结论:环磷酰胺与泼尼松联用治疗可有效地改善SLE患者外周血淋巴细胞亚群比例,减轻疾病的严重程度。
Objective: To evaluate the effect of cyclophosphamide combined with prednisone on peripheral T lymphocyte subsets in patients with systemic lupus erythematosus (SLE). Methods: One hundred and fifteen patients with SLE admitted to our hospital from January 2014 to January 2015 were divided into control group (55 cases) and observation group (60 cases). Patients in the control group were given routine treatment. Patients in the observation group On the basis of the control group, both cyclophosphamide and prednisone were given. The changes of peripheral blood lymphocyte subsets in patients before and after treatment were detected by flow cytometry. Results: The T lymphocyte subsets, CD3 (+), CD4 (+) and CD4 (+) / CD8 (+) ratio of peripheral blood in the observation group were significantly higher than those in the control group The number of peripheral blood CD8 (+) T lymphocytes of the patients in the observation group was significantly lower than that in the control group (P <0.05). The number of NK cells in the peripheral blood of the observation group was significantly higher than that of the control group (P <0.05); the number of B lymphocytes was significantly lower (P <0.05). After treatment, the activity of SLE in the observation group was scored according to the method of literature [6], which was significantly lower than that of the control group (P <0.05). The incidence of adverse reactions in both groups after treatment The difference was not statistically significant (P> 0.05). Conclusion: The combination of cyclophosphamide and prednisone can effectively improve the proportion of peripheral blood lymphocyte subsets in patients with SLE and reduce the severity of the disease.