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目的：研究慢性病毒性肝炎病理改变与肝纤维化关系。方法：对３７例慢性病毒性肝炎（ＣＶＨ）肝组织进行病理学检查，并检测其血清Ⅲ型前胶原肽（ＰⅢＰ）、层粘蛋白（ＬＮ）、Ⅳ型胶原（ⅣＣ）、透明质酸（ＨＡ）等。结果：汇管区炎细胞浸润明显患者血清ＬＮ、ⅣＣ、ＨＡ明显升高。ＰⅢＰ在碎屑样坏死时明显升高。小叶内炎细胞浸润明显及有桥接样坏死者，血清ＬＮ、ⅣＣ、ＨＡ均明显升高。淤胆患者血清ＨＡ较无淤胆患者升高明显。同时伴随肝细胞再生者血清ＬＮ亦明显升高。结论：ＣＶＨ的炎症、坏死、肝细胞再生以及淤胆等病理过程均与肝纤维化的形成有关
Objective: To study the relationship between pathological changes of chronic viral hepatitis and hepatic fibrosis. Methods: Thirty - seven patients with chronic viral hepatitis (CVH) were studied by pathology. The serum levels of P Ⅲ P, LN, Ⅳ C, HA )Wait. Results: Serum LN, Ⅳ C and HA were significantly increased in patients with obvious inflammatory cell infiltration. PⅢP was significantly higher in debris-like necrosis. Lobular inflammatory cell infiltration was obvious and there were bridge-like necrosis, serum LN, Ⅳ C, HA were significantly increased. Cholesteric patients with serum HA than non-cholestatic patients increased significantly. At the same time with liver cell regeneration, serum LN was also significantly higher. Conclusion: The pathology of inflammation, necrosis, hepatocyte regeneration and cholestasis of CVH are related to the formation of liver fibrosis