赤芍对移植性S-180实体瘤有明显抑制作用;显著增强环磷酰胺、氨甲喋呤等药物对S-180实体瘤和215小鼠白血病的抗癌疗效。赤芍可提高S-180腹水癌细胞内,S-180实体瘤和Lewis肺癌组织中cAMP的水平。Lewis肺癌和S-180实体瘤小鼠与相应正常小鼠血浆中cAMP水平无显著差异,赤芍对荷瘤小鼠血浆中cAMP含量亦无明显影响。 Radix Paeoniae Radix was significantly inhibited on transplanted S-180 solid tumors; it significantly enhanced the anti-cancer efficacy of cyclophosphamide, methotrexate and other drugs on solid tumors of S-180 and 215 mice. Radix Paeoniae Radix can increase the levels of cAMP in S-180 ascites carcinoma cells, S-180 solid tumors and Lewis lung cancer tissues. There was no significant difference in plasma cAMP levels between mice with Lewis lung cancer and S-180 solid tumors and corresponding normal mice. Chitosan also had no significant effect on plasma cAMP levels in tumor-bearing mice.