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为了探讨恶性淋巴瘤（ＭＬ）染色体异常与组织学分型的相关性及其与ＭＬ的发生的关系，采用改良直接法和短期培养法快速制备淋巴结标本，对４２例ＭＬ进行了细胞遗传学研究，３５例获得满意分裂相。结果显示：所获得的ＭＬ实体瘤染色体均有不同程度的数目和／或结构克隆性异常，多涉及１，２，３，５，６，７，８，１１，１２，１３，１４，１７，１８号及Ｙ等染色体改变。不同的染色体畸变与ＭＬ的组织学分型有关。多种染色体结构重排涉及１４ｑ１１、１４ｑ３２附近，提示１４ｑ１１、１４ｑ３２的断裂重排与ＭＬ的发生有关系。另外，ＨＤ中结构重排易涉及１ｐ１３、１３ｑ３３，提示该部位的断裂重排与ＨＤ的发生有关。认为细胞遗传学与组织病理学结合起来，有助于ＭＬ的分类，并对指导临床治疗和判断预后具有重要意义。
In order to investigate the relationship between the chromosomal abnormality of lymphoma (ML) and histological type and its relationship with the occurrence of ML, the lymph node specimens were rapidly prepared by modified direct method and short-term culture method, and 42 cases of ML were studied by cytogenetics. Thirty-five patients received a satisfactory split phase. The results showed that the obtained ML solid tumors had different degrees of chromosome number and/or structural clonality, which involved 1,2,3,5,6,7,8,11,12,13,14,17, 18th and Y chromosome changes. Different chromosomal aberrations are related to histological subtypes of ML. The rearrangement of multiple chromosome structures involves the vicinity of 14q11 and 14q32, suggesting that the rearrangements of 14q11 and 14q32 are related to the occurrence of ML. In addition, the structural rearrangement in HD involves 1p13 and 13q33, suggesting that the rearrangement of the site is related to the occurrence of HD. It is believed that the combination of cytogenetics and histopathology contributes to the classification of ML and is of great significance in guiding clinical treatment and judging prognosis.