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目的观察米非司酮配伍米索前列醇用于负压吸引流产术的效果。方法对100例妊娠7～10周要求终止妊娠的妇女予米非司酮75mg口服,每日早上空腹口服,连续2d,第3天负压吸引流产术前肛门置入米索前列醇400μg(观察组),另选择100例情况相同的妇女在术中宫颈注射利多卡因5ml(对照组)。观察两组妇女手术中宫颈松弛程度、疼痛程度、人工流产综合征(RAAS)发生率、宫颈宫腔粘连发生率、出血量及药物不良反应。结果两组妇女宫颈松弛效果比较,差异有统计学意义(P<0.01);两组妇女术中疼痛程度比较,差异有统计学意义(P<0.01);两组妇女人工流产综合征(RAAS)发生率、宫颈宫腔粘连发生率比较,差异有统计学意义(P<0.05);两组妇女术中出血量比较,差异无统计学意义(P>0.05);两组孕妇均有少数出现药物不良反应,症状轻微,短时间内消失。结论米非司酮配伍米索前列醇用于负压吸引流产术前,方法简便、安全、有效,值得在临床上推广。
Objective To observe the effect of mifepristone and misoprostol for negative pressure abortion. Methods 100 women with termination of pregnancy from 7 to 10 weeks of gestation were given orally with mifepristone 75mg. They were taken orally fasting on the morning of the morning for 2 days. On the 3rd day, 400g of misoprostol Group), another 100 cases of women with the same situation were selected intraoperatively to inject lidocaine 5ml (control group). The degree of cervical relaxation, the degree of pain, the incidence of induced abortion syndrome (RAAS), the incidence of cervical intrauterine adhesions, bleeding volume and adverse drug reactions were observed in the two groups of women. Results There were significant differences in cervical relaxation between the two groups (P <0.01). There was significant difference in the degree of intraoperative pain between the two groups (P <0.01). Two groups of women with induced abortion syndrome (RAAS) (P <0.05). There was no significant difference in the intraoperative blood loss between the two groups (P> 0.05). There were a few cases of pregnant women in both groups Adverse reactions, mild symptoms, disappear within a short time. Conclusion Mifepristone with misoprostol for vacuum suction abortion before surgery, the method is simple, safe and effective, it is worth to be clinically promoted.