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目的探讨白三烯C4在哮喘发病中的作用。方法采用ELISA法,分别测定56例支气管哮喘发作期,60例缓解期以及60例正常对照组血清中LTC4水平。结果哮喘发作组和哮喘缓解组LTC4(14.63±2.85)ng/mL和(13.92±2.46)ng/mL水平显著高于正常对照组(2.42±0.36)ng/mL。而哮喘患者急性发作组和缓解组之间比较差异无统计学意义。结论LTC4是哮喘发生发展的重要炎性因子。
Objective To investigate the role of leukotriene C4 in the pathogenesis of asthma. Methods The serum levels of LTC4 in 56 cases of bronchial asthma attack, 60 cases of remission and 60 cases of normal control were measured by ELISA. Results The levels of LTC4 (14.63 ± 2.85) ng / mL and (13.92 ± 2.46) ng / mL in the asthma attack group and the asthma relief group were significantly higher than those in the normal control group (2.42 ± 0.36) ng / mL. There was no significant difference between acute attack group and remission group in asthma patients. Conclusion LTC4 is an important inflammatory factor in the development of asthma.