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我院肿瘤研究室董来炜教授等先后用甲基—硝基—亚硝基胍(MNNG)诱发狗胃癌模型,试图通过复制狗胃癌,进一步探讨早期胃癌的病理形态变化及癌前病变与胃癌发生的关系,3年来在10只杂种家狗中,通过定期胃镜活检和死后系统解剖。共检出3只狗在给药200～337天后出现微小癌灶16个。湖南省科委于1985年4月24日在上海召开了“MNNG诱发狗微小胃癌和癌前期疾病的
Prof. Dong Laiwei from Cancer Research Center of our hospital has used methyl-nitro-nitrosoguanidine (MNNG) to induce dog gastric cancer models, attempting to further explore the pathological changes of early gastric cancer, precancerous lesions and gastric cancer by replicating dog gastric cancer. The relationship, over the past 3 years in 10 hybrid domestic dogs, was performed through regular gastroscopy biopsy and post-mortem system dissection. A total of 16 small cancer lesions were detected in 3 dogs after 200-337 days of dosing. Hunan Provincial Science and Technology Commission held a MNNG-induced dog tiny stomach cancer and precancerous disease on April 24, 1985 in Shanghai.