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目的:通过对子宫肌瘤的细胞增殖和凋亡的检测,探讨子宫肌瘤的生长发病机理,为临床治疗子宫肌瘤提供理论基础。方法:应用免疫组织化学Envision~(TM)法,对手术切除的63例子宫肌瘤的石腊标本及邻近子宫肌组织蜡块标本进行PCNA、Bcl-2蛋白含量检测分析。结果:在子宫肌瘤组织中,PCNA、Bcl-2蛋白明显高于子宫肌组织(对照组)(P<0.001),且分泌期高于增殖期(P<0.005)。结论:子宫肌瘤的发生与细胞增殖抗原(PCNA)及Bcl-2凋亡有关。
Objective: To investigate the pathogenesis of uterine leiomyoma by detecting the cell proliferation and apoptosis of uterine fibroids and provide the theoretical basis for clinical treatment of uterine fibroids. Methods: Immunohistochemistry (Envision TM) method was used to detect the contents of PCNA and Bcl-2 protein in paraffin-embedded specimens of paraffin-embedded specimens from 63 paraffin-embedded specimens of uterine fibroids and adjacent myometrium. Results: The expression of PCNA and Bcl-2 protein in uterine fibroids was significantly higher than that in uterine muscle (control group) (P <0.001), and the secretion was higher than that in proliferative phase (P <0.005). Conclusion: The occurrence of uterine fibroids is related to the proliferation of PCNA and Bcl-2.