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[目的]比较氨茶碱联合纳洛酮与单用氨茶碱药物治疗早产儿原发性呼吸暂停的疗效。[方法]采用Review Manager 5.0分析软件,对国内22篇有关氨茶碱联合纳洛酮治疗早产儿原发性呼吸暂停疗效的研究结果进行固定效应模型的Meta分析。[结果]氨茶碱联合纳洛酮治疗早产儿原发性呼吸暂停的显效率和总有效率均高于单用氨茶碱组,合并RR分别为1.65和1.35,95%可信区间分别为1.49～1.83和1.28～1.42.[结论]氨茶碱联合纳洛酮比单纯氨茶碱治疗早产儿原发性呼吸暂停疗效更好。
[Objective] To compare the efficacy of aminophylline combined with naloxone and aminophylline alone in the treatment of premature infants with primary apnea. [Methods] The Review Manager 5.0 software was used to analyze the effects of aminophylline combined with naloxone on the treatment of primary apnea in preterm infants. [Results] The effective rate and total effective rate of aminophylline combined with naloxone in the treatment of premature infants with primary apnea were all higher than those of the aminophylline alone group. The combined RRs were 1.65 and 1.35, respectively. The 95% confidence intervals were 1.49-1.83 and 1.28-1.42. [Conclusion] The combination of aminophylline and naloxone is more effective than aminophylline alone in the treatment of premature infants with primary apnea.