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目的:评价盐酸坦索罗辛治疗不同体积BPH患者的临床疗效及安全性。方法:采用盐酸坦索罗辛治疗BPH患者68例,其中Ⅰ组36例,体积<50 ml;Ⅱ组32例,体积≥50 ml,均给予盐酸坦索罗辛0.2 mg,口服,每天1次,服用3个月。回顾性分析服用前后国际前列腺症状评分(IPSS)、生活质量指数(QOL)、最大尿流率(Qmax)、剩余尿量(PVR)及血压的变化。结果:两组患者IPSS、QOL、Qmax均有所改善,减少了PVR,Ⅰ组优于Ⅱ组,差别有统计学意义,但治疗前后及两组间血压、前列腺体积差别无统计学意义。有10例发生了不良反应,其中头晕、头痛3例,恶心、呕吐2例,乏力1例,均于服药3天后症状消失;逆行射精4例,未发现过敏反应及体位性低血压。结论:盐酸坦索罗辛能明显改善BPH患者下尿路梗阻症状,无严重不良反应,对前列腺体积小于50 ml者效果更明显。
Objective: To evaluate the clinical efficacy and safety of tamsulosin hydrochloride in patients with different volumes of BPH. Methods: Sixty-eight patients with BPH were treated with tamsulosin hydrochloride, in which 36 patients in group Ⅰ had a volume of less than 50 ml, and 32 patients in group Ⅱ had a volume of ≥50 ml. Patients were given tamsulosin hydrochloride 0.2 mg orally once daily Take 3 months. The changes of International Prostate Symptom Score (IPSS), Quality of Life Index (QOL), Qmax, Residual Urine Volume (PVR) and blood pressure were analyzed retrospectively. Results: IPSS, QOL and Qmax were improved in both groups, PVR was decreased, and group Ⅰ was superior to group Ⅱ, the difference was statistically significant, but there was no significant difference in blood pressure and prostate volume before and after treatment and between two groups. There were 10 cases of adverse reactions, including dizziness, headache in 3 cases, nausea, vomiting in 2 cases, 1 case of fatigue, were symptoms after 3 days of medication disappeared; retrograde ejaculation in 4 cases, no allergic reactions and orthostatic hypotension was found. Conclusion: Tamsulosin hydrochloride can significantly improve the symptoms of lower urinary tract obstruction in patients with BPH, without serious adverse reactions, the effects of prostate volume less than 50 ml are more obvious.