神经退化性疾病患者经常发生神经精神症状和行为改变。神经病学、神经递质和分子遗传学的研究增长了识别介导神经退化性疾病行为变化的特异机制,提供了寻找有效介入治疗的平台。抗痴呆药临床试验的行为效果测定为评价治疗的有效性提供了重要手段,临床方法学和行为测定法的进步,促进了对此重要治疗靶标的药物开发。 Patients with neurodegenerative disorders often experience neuropsychiatric symptoms and behavioral changes. Neuroscience, neurotransmitters, and molecular genetics have increased the identification of specific mechanisms that mediate behavioral changes in neurodegenerative diseases, providing a platform to find effective interventional treatments. Determination of the behavioral effects of clinical trials of anti-dementia drugs provides an important tool for assessing the effectiveness of treatment, and advances in clinical methodologies and behavioral assays have led to the development of drugs for this important therapeutic target.