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目的：探讨膀胱癌、肾细胞癌突变型ｐ５３蛋白的高表达与预后之间的关系。方法：采用免疫组化ＡＢＣ法分别对４０例膀胱癌和３４例肾细胞癌组织标本进行ｐ５３ 蛋白表达的研究。结果：膀胱癌、肾细胞癌突变型ｐ５３ 基因癌蛋白的高表达阳性率为３７．５％ 和３２．４％ ，而正常肾组织及空白对照均为阴性。膀胱癌ｐ５３ 阴性、阳性患者的５年生存率分别为８４．０％ 、６６．７％ ，两组比较无显著性差异（Ｐ＞ ０．０５）。肾癌ｐ５３ 蛋白表达阴性、阳性患者的５ 年存活率分别为６９．６％ 、２６．６％ ，两组比较无显著性差异（Ｐ＞ ０．０５）。结论：提示ｐ５３ 基因高表达可能成为恶性肿瘤标志之一。突变型ｐ５３ 基因表达可能与膀胱癌、肾细胞癌的预后无关。
Objective: To investigate the relationship between the high expression of mutant p53 protein and prognosis in bladder cancer and renal cell carcinoma. Methods: The expression of p53 protein in 40 cases of bladder cancer and 34 cases of renal cell carcinoma was studied by immunohistochemical ABC method. Results: The positive rates of high expression of mutant p53 gene oncoprotein in bladder cancer and renal cell carcinoma were 37.5% and 32.4%, but negative in normal kidney tissue and blank control. The 5-year survival rates of p53-negative and positive patients with bladder cancer were 84.0% and 66.7%, respectively, and there was no significant difference between the two groups (P> 0.05). The 5-year survival rates of patients with negative and positive p53 protein expression in kidney cancer were 69.6% and 26.6%, respectively, and there was no significant difference between the two groups (P> 0.05). Conclusion: It is suggested that the high expression of p53 gene may be one of the markers of malignant tumors. The expression of mutant p53 gene may not be related to the prognosis of bladder cancer or renal cell carcinoma.