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阻塞性黄疸病人术后肾功能衰竭的发生率为3～50%,其死亡率高达25～80%.发生肾功能损害的黄疽病人,其外围循环中常并存细菌内毒素,是一种革兰氏阴性菌的脂多糖细胞膜,此内毒素来源于肠道.阻塞性黄疸时从肠道内吸收的内毒素剧增,可能与小肠内胆盐的缺乏有关.本文旨在研究黄疽与非黄疸病人小肠内菌群与门脉、体循环内毒素血症的关系,以及胆盐在预防内毒素吸收的作用.作者将病例分成3组,阻塞性黄疸组与非阻塞性黄疸组(对照)各25例,另外8例阻塞性黄疽病人术前口服去氧胆酸钠,每8小时500mg,共48小时.手术前后除常规实验室检查外,测24小时尿肌酸酐清除
The incidence of postoperative renal failure in patients with obstructive jaundice is 3 to 50%, the mortality rate as high as 25 to 80% .Jaundice patients with renal dysfunction, the peripheral circulation often coexist bacterial endotoxin, is a Gram Negative bacterial lipopolysaccharide cell membrane, the endotoxin from the intestine .Oclusion of obstructive jaundice when the endotoxin absorption from the intestine increased sharply, may be related to the lack of salt in the small intestine.This paper aims to study jaundice and jaundice patients Intestinal flora and the portal vein, systemic endotoxemia, as well as the role of bile salts in the prevention of endotoxin absorption.The patients were divided into 3 groups, obstructive jaundice group and non-obstructive jaundice group (control) 25 cases each , Another 8 patients with obstructive jaundice preoperative oral sodium deoxycholate, 500mg every 8 hours, a total of 48 hours before and after surgery in addition to routine laboratory tests, measured 24-hour urine creatinine clearance